JOSH Hartnett could be making a return to the big screen with a role in a new indie drama.

The actor is in talks to star in 'A Moment To Remember', directed by Ben Lewin, Deadline reports.

The movie tells the tale of a couple whose marriage suffers when the woman is diagnosed with a rare form of early-onset Alzheimer's disease.

Actress Jena Malone has been confirmed as the star taking on the female lead role.

The script was written by Lewin and 'Erin Brockovich' writer Susannah Grant. Production is slated to begin in November.